The disadvantaged position of indigenous employees in the workplace has been an issue concerned with the society. Most past studies on the indigenous employment difficulties focus on the dimensions of job stress, work involvement, work values, and work satisfaction, from the perspectives on organizational identity, ethic awareness, and adaptive strategy. The adversity quotient was rarely used to study the work-related dimension. Therefore, this research aims to explore the situations the indigenous employees encounter in their workplaces, in order to analyze the impact of job stress and resignation intention through the adversity quotient and work values, as intervening variables. This study conducted a questionnaire survey and distributed 300 questionnaires. A total of 300 effective questionnaires were retrieved, with an effective response rate was 100%. The statistical analysis software SPSS 23 was used to analyze the data, and the results are as follows: (1) The significant relationship between Job stress and Adversity Quotient (AQ); (2) The significant relationship between Adversity Quotient (AQ) and employees satisfaction; (3) The significant relationship between Adversity Quotient (AQ) and work performance; (4) The significant relationship between employees satisfaction and work performance; (5) The significant relationship between job stress and employees satisfaction; (6) The significant relationship between job stress and work performance. The research provides business organizations with the measurement of indigenous employees' performance in facing adversity and ability in crisis control using the measurement of adversity quotient (AQ) on job stress and work performance. The findings can serve as a reference for hiring indigenous employees.