The purpose of this study is to explore the work adjustment factors that influence the Taiwanese expatriates when they work in the U.S. Questionnaires were mailed to HR Department in 93 subsidiaries which were all selected from TSEC (Taiwan Stock Exchange Corporation) Market in Taiwan. A total of 186 subjects were asked to respond to the questionnaire. The results indicated that language, support, relationship, role novelty, role ambiguity, role conflict and role discretion were related to expatriates' adjustment to the work. However, previous experience was not related to work adjustment. Family support and satisfactory work adjustment were related to intent to stay in the overseas assignment. Equally important, support, role conflict, and role ambiguity are the most influential on expatriate work adjustment.